Subj : Alphabet's AI drug trials ¨, Jack Dorsey's WhatsApp competitor ¨, copyleft vs permissive licenses ¨¨ To : All From : TLDR Date : Tue Jul 08 2025 10:46:35 --OOtqTv52 Content-Type: text/plain; charset=utf-8 Content-Transfer-Encoding: quoted-printable Isomorphic Labs, Alphabet's secretive drug discovery arm, was born from o= ne of DeepMind's most celebrated breakthroughs, AlphaFold=C2=A0=E2=80= =8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0= =E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2= =A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C= =C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80= =8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0= =E2=80=8C=C2=A0=E2=80=8C=C2=A0=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80= =8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0= =E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2= =A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C= =C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80= =8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0 = Sign Up [1] |Advertise [2]|View Online [3]=20 =09=09TLDR=20 =09= =09TOGETHER WITH [Pacaso] [4] TLDR 2025-07-08 3 THINGS VENTURE C= APITAL FIRMS LOOK FOR (SPONSOR) [4]=20 For VCs, the best investments ch= eck three boxes: a massive market, a clear pain point, and founder-market= fit.=C2=A0 No wonder prominent firms like Maveron backed Pacaso. = In the $1.3 trillion vacation home market, second homes were either to= o expensive or too much hassle. So after successfully exiting his previou= s business, a proven real estate founder applied his proptech expertise [= 4], selling fractions of homes and managing everything through streamline= d tech.=C2=A0 That approach has earned Pacaso $110m+ in gross profits = to date, including 41% YoY growth last year alone, across 2,000+ happy = homeowners. Join major VCs like Greycroft as a Pacaso investor for jus= t $2.90/share. =F0=9F=93=B1=20 BIG TECH & STARTUPS ALPHABET= 'S ISOMORPHIC LABS HAS GRAND AMBITIONS TO =E2=80=98SOLVE ALL DISEASES' WI= TH AI. NOW, IT'S GEARING UP FOR ITS FIRST HUMAN TRIALS (3 MINUTE READ) [5= ]=20 Isomorphic Labs, Alphabet's secretive drug discovery arm, is pre= paring to launch human trials of AI-designed drugs. The company was born = from one of DeepMind's most celebrated breakthroughs, AlphaFold, an AI sy= stem capable of predicting protein structures and interactions with a hig= h level of accuracy. The system has helped researchers design medicines f= aster and more precisely.=20 JACK DORSEY LAUNCHES A WHATSAPP MESSAGING = RIVAL BUILT ON BLUETOOTH (3 MINUTE READ) [6]=20 Bitchat is a decentra= lized, peer-to-peer messaging app that works entirely over Bluetooth mesh= networks - no internet, central servers, phone numbers, or emails requir= ed. It enables ephemeral, encrypted communication - nearby devices form c= lusters and pass messages from device to device, allowing them to reach p= eers beyond standard range, even without Wi-Fi or cell service. Messages = are stored only on-device, disappear by default, and never touch centrali= zed infrastructure. A beta version of Bitchat is currently live on Test= Flight.=20 =F0=9F=9A=80=20 SCIENCE & FUTURISTIC TECHNOLOGY CREA= TING THERAPEUTIC ABUNDANCE (22 MINUTE READ) [7]=20 The invention of new= medicines is limited by our knowledge of cells and molecules that can be= manipulated to treat disease. The cost of discovering new medicines is i= ncreasing. New technologies have the potential to unlock an era of target= abundance and reverse the long decline in research and development produ= ctivity. This could be one of AI's most important impacts.=20 NUCLEAR= REACTORS SMALLER THAN A SEMI TRUCK TO BE TESTED IN IDAHO (4 MINUTE READ)= [8]=20 The US Department of Energy (DoE) has conditionally selected = Westinghouse's trailer-sized eVinci test reactor and Radiant's Kaleidos u= nit to conduct the first fueled microreactor experiments at its Demonstra= tion of Microreactor Experiments (DOME) facility at Idaho National Labora= tory. The DOME project considers anything under 50 MW of power to be a mi= croreactor - the eVinci is designed to produce 5 megawatts, and the Kalei= dos can output 1.2 megawatts. The DoE hopes that microreactors can be use= d to power small, remote sites. DOME is designed to be up and running by = early 2026. It will operate one experiment at a time for six months.=20 = =F0=9F=92=BB=20 PROGRAMMING, DESIGN & DATA SCIENCE DELVE GENERA= TED $1M IN PIPELINE FROM TLDR NEWSLETTER ADS (SPONSOR) [9]=20 Delve r= an 4 ads across 2 TLDR newsletters and brought in 66 leads, with a meanin= gful chunk from enterprise. The result: $1M in attributed pipeline and a = 52x ROI. This case study breaks down their strategy, results, and exam= ple ads. Read the Delve case study. [9] HANDLING UNIQUE INDEXES = ON LARGE DATA IN POSTGRESQL (10 MINUTE READ) [10]=20 PostgreSQL has a= limitation on unique index entries larger than 1/3 of a buffer page. The= 1/3 page size limit exists to ensure efficient page splitting. To overco= me the restriction, introduce a new field that stores a hash of the large= field. This allows you to store really large data inside databases, even= with unique constraints.=20 ADDING A FEATURE BECAUSE CHATGPT INCORRECT= LY THINKS IT EXISTS (5 MINUTE READ) [11]=20 Soundslice is a service t= hat scans sheet music from photographs so users can listen, edit, and pra= ctice. Over the past few months, the team at Soundslice started noticing = that their error logs were full of ASCII tablature, a way of notating mus= ic for guitar that the service didn't support. The team discovered that C= hatGPT was hallucinating instructions to users and telling them to go to = Soundslice and use a feature that didn't exist. Instead of posting a noti= ce telling users that ChatGPT was incorrect, the team decided to build th= e feature instead.=20 =F0=9F=8E=81=20 MISCELLANEOUS WHY I USE= D TO PREFER PERMISSIVE LICENSES AND NOW FAVOR COPYLEFT (10 MINUTE READ) [= 12]=20 Free open source software is usually published under one of two = major categories of copyright licenses: permissive licenses, which freely= share with everyone, or copyleft licenses, which freely share only wit= h those who are also willing to freely share. Copyleft creates a large po= ol of code that developers can only legally use if they are willing to sh= are the source code of anything they build on it, making it a very broad-= based and neutral way of incentivizing more diffusion. It does not favor = specific actors nor create roles for active parameter setting by central = planners.=20 THE BROKEN MICROSOFT PACT: LAYOFFS AND PERFORMANCE MANAGEM= ENT (9 MINUTE READ) [13]=20 There are stories of people who have been= with Microsoft for 20 years, who grew up with the company, and who never= had to worry about sudden changes. While the performance management syst= em had its quirks, there was an understanding that if you did solid work,= you'd have a place. Workers at Microsoft received below-market-rate pay = in exchange for stability, a reasonable work-life balance, and the prom= ise of no layoffs - this is no longer the case. This shift was almost exp= ected: Microsoft's performance management challenges made layoffs a more = attractive option than addressing individual performance issues systemati= cally.=20 =E2=9A=A1=20 QUICK LINKS OPENAI RAMPS UP STOCK PAY TO= $4.4 BILLION TO COMBAT META'S COSTLY TALENT RAIDS (3 MINUTE READ) [14] = OpenAI is dramatically increasing its employee stock compensation to= defend against rival Meta's poaching.=20 WAYMO ROBOTAXIS ARE HEADING= TO PHILADELPHIA AND NYC (2 MINUTE READ) [15]=20 Waymo kicked off two= 'road trips' to Philadelphia and New York City yesterday - these branded= 'road trips' don't necessarily signal a commercial launch, but it has ha= ppened before.=20 APPLE LOSES TOP AI MODELS EXECUTIVE TO META'S HIRING = SPREE (6 MINUTE READ) [16]=20 Ruoming Pang, the executive in charge o= f Apple's foundation models team, is departing the company for Meta, who = offered Pang a package worth tens of millions of dollars per year.=20 = WHAT WOULD STRIPE L1 LOOK LIKE? (13 MINUTE READ) [17]=20 A Stripe L1 s= hould support stablecoin use and Stripe L1 integration for customer payme= nts and merchant settlement.=20 TECH HIRING IS NOT THE SAME AS IT WAS E= VEN A YEAR AGO (1 MINUTE READ) [18]=20 Hiring for new graduates in Bi= g Tech is down 25% and -11% for startups.=20 UNLESS USERS TAKE ACTION= , ANDROID WILL LET GEMINI ACCESS THIRD-PARTY APPS (6 MINUTE READ) [19] = Google is implementing a change that will enable its Gemini AI engin= e to interact with third-party apps even if users have configured their= devices to block such interactions.=20 Love TLDR? Tell your friends a= nd get rewards! Share your referral link below with friends to get fr= ee TLDR swag!=20 https://refer.tldr.tech/1fd848fa/ [20]=20 =09=09 Tr= ack your referrals here. [21]=20 Want to advertise in TLDR? =F0=9F=93= =B0 If your company is interested in reaching an audience of tech e= xecutives, decision-makers and engineers, you may want to ADVERTISE WITH = US [22].=20 Want to work at TLDR? =F0=9F=92=BC APPLY HERE [23] or = send a friend's resume to jobs@tldr.tech and get $1k if we hire them!=20 = If you have any comments or feedback, just respond to this email!=20 = Thanks for reading,=20 Dan Ni [24] & Stephen Flanders [25]=20 Manage= your subscriptions [26] to our other newsletters on tech, startups, and = programming. Or if TLDR isn't for you, please unsubscribe [27].=20 = Links: ------ [1] https://tldr.tech/signup?utm_source=3Dtldr [2= ] https://advertise.tldr.tech/?utm_source=3Dtldr&utm_medium=3Dnewsletter&ut= m_campaign=3Dadvertisetopnav [3] https://a.tldrnewsletter.com/web-version= ?ep=3D1&lc=3Db5bb39ac-a04f-11ee-8692-6388dbdd6fd1&p=3Da76cca6c-5bd0-11f0-b0= 3e-ed28c90d6451&pt=3Dcampaign&t=3D1751971595&s=3D700a60ea8abc1b4217e52720c4= 80e85158489f5b65886ee123de3365482a218d [4] https://invest.pacaso.com/?utm= _source=3Demail&utm_medium=3Dpaid-partnership&utm_campaign=3Dpartnership30-= 362_07-08_10758330809 [5] https://www.msn.com/en-us/health/other/alphabet= -s-isomorphic-labs-has-grand-ambitions-to-solve-all-diseases-with-ai-now-it= -s-gearing-up-for-its-first-human-trials/ar-AA1I44pq?utm_source=3Dtldrnewsl= etter [6] https://www.cnbc.com/2025/07/07/jack-dorsey-whatsapp-bluetooth.= html?utm_source=3Dtldrnewsletter [7] https://blog.jck.bio/p/creating-ther= apeutic-abundance?utm_source=3Dtldrnewsletter [8] https://www.theregister= ..com/2025/07/07/trailer_sized_microreactors/?utm_source=3Dtldrnewsletter = [9] https://advertise.tldr.tech/case-studies/delve-drives-1m-in-attributed-= pipeline-52x-roi-through-tldr-ads/?utm_source=3Dtldr&utm_medium=3Dnewslette= r&utm_campaign=3Dsecondary07082025 [10] https://volodymyrpotiichuk.com/bl= og/articles/unique-indexes-on-large-data-in-postgres-sql?utm_source=3Dtldrn= ewsletter [11] https://www.holovaty.com/writing/chatgpt-fake-feature/?utm= _source=3Dtldrnewsletter [12] https://vitalik.eth.limo/general/2025/07/07= /copyleft.html?utm_source=3Dtldrnewsletter [13] https://danielsada.tech/b= log/microsoft-pact/?utm_source=3Dtldrnewsletter [14] https://links.tldrne= wsletter.com/TkYpjp [15] https://techcrunch.com/2025/07/07/waymo-heading-= to-philadelphia-and-nyc/?utm_source=3Dtldrnewsletter [16] https://links.t= ldrnewsletter.com/MxPt5w [17] https://links.tldrnewsletter.com/y6RVhe [= 18] https://threadreaderapp.com/thread/1942251177779024262.html?utm_source= =3Dtldrnewsletter [19] https://arstechnica.com/security/2025/07/unless-us= ers-take-action-android-will-let-gemini-access-third-party-apps/?utm_source= =3Dtldrnewsletter [20] https://refer.tldr.tech/1fd848fa/ [21] https://h= ub.sparklp.co/sub_32edf8dd66ae/1 [22] https://advertise.tldr.tech/?utm_so= urce=3Dtldr&utm_medium=3Dnewsletter&utm_campaign=3Dadvertisecta [23] http= s://jobs.ashbyhq.com/tldr.tech [24] https://twitter.com/tldrdan [25] ht= tps://twitter.com/SteveFlanders22 [26] https://tldr.tech/tech/manage?emai= l=3Dtldr%40synchro.net [27] https://a.tldrnewsletter.com/unsubscribe?ep= =3D1&l=3Dcfa2d55a-b7be-11e8-a3c9-06b79b628af2&lc=3Db5bb39ac-a04f-11ee-8692-= 6388dbdd6fd1&p=3Da76cca6c-5bd0-11f0-b03e-ed28c90d6451&pt=3Dcampaign&pv=3D4&= spa=3D1751968881&t=3D1751971595&s=3Dd6c72257b571833e22412f3cfc7bf2c75bed62b= 697d238404be006d1c651d194 --OOtqTv52 Content-Type: text/html; charset=utf-8 Content-Transfer-Encoding: quoted-printable TLDR
Isomorphic= Labs, Alphabet's secretive drug discovery arm, was born from one of D= eepMind's most celebrated breakthroughs, AlphaFold =E2=80=8C = ;=E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C = ;=E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C = ;=E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C = ;=E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C = ;=E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C = ; =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80= =8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80= =8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80= =8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80= =8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80= =8C =E2=80=8C 

TLDR

Together With 3D"Pacaso"<= /td>

TLDR 2025-07-08

3 things venture capital fi= rms look for (Sponsor)

For VCs, the best investments check thr= ee boxes: a massive market, a clear pain point, and founder-market fit.&nbs= p;

No wonder prominent firms like Maveron backed Pacaso.

In = the $1.3 trillion vacation home market, second homes were either too expens= ive or too much hassle. So after successfully exiting his previous business, a proven= real estate founder applied his proptech expertise, selling fra= ctions of homes and managing everything through streamlined tech. 

That approach has earned Pacaso $110m+ in gross profits to date, includi= ng 41% YoY growth last year alone, across 2,000+ happy homeowners.

Join major VCs like Greycroft as a Pacaso investor for just $2.90/share.

=F0=9F= =93=B1

Big Tech & Startups

Alphabet's Isomorphic Labs = has grand ambitions to =E2=80=98solve all diseases' with AI. Now, it's gear= ing up for its first human trials (3 minute read)

Isomorphic Labs, Alphabet's secretive d= rug discovery arm, is preparing to launch human trials of AI-designed drugs= .. The company was born from one of DeepMind's most celebrated breakthroughs= , AlphaFold, an AI system capable of predicting protein structures and inte= ractions with a high level of accuracy. The system has helped researchers d= esign medicines faster and more precisely.
Jack Dorsey launches a What= sApp messaging rival built on Bluetooth (3 minute read)

Bitchat is a decentralized, peer-to-pee= r messaging app that works entirely over Bluetooth mesh networks - no inter= net, central servers, phone numbers, or emails required. It enables ephemer= al, encrypted communication - nearby devices form clusters and pass message= s from device to device, allowing them to reach peers beyond standard range= , even without Wi-Fi or cell service. Messages are stored only on-device, d= isappear by default, and never touch centralized infrastructure. A beta ver= sion of Bitchat is currently live on TestFlight.
=F0=9F= =9A=80

Science & Futuristic Technology

Creating therapeutic abunda= nce (22 minute read)

The invention of new medicines is limit= ed by our knowledge of cells and molecules that can be manipulated to treat= disease. The cost of discovering new medicines is increasing. New technolo= gies have the potential to unlock an era of target abundance and reverse th= e long decline in research and development productivity. This could be one = of AI's most important impacts.
Nuclear reactors smaller th= an a semi truck to be tested in Idaho (4 minute read)

The US Department of Energy (DoE) has c= onditionally selected Westinghouse's trailer-sized eVinci test reactor and = Radiant's Kaleidos unit to conduct the first fueled microreactor experiment= s at its Demonstration of Microreactor Experiments (DOME) facility at Idaho= National Laboratory. The DOME project considers anything under 50 MW of po= wer to be a microreactor - the eVinci is designed to produce 5 megawatts, a= nd the Kaleidos can output 1.2 megawatts. The DoE hopes that microreactors = can be used to power small, remote sites. DOME is designed to be up and run= ning by early 2026. It will operate one experiment at a time for six months= ..
=F0=9F= =92=BB

Programming, Design & Data Science

Delve generated $1M in pipe= line from TLDR newsletter ads (Sponsor)

Delve ran 4 ads across 2 TLDR newslette= rs and brought in 66 leads, with a meaningful chunk from enterprise. The re= sult: $1M in attributed pipeline and a 52x ROI.

This case study br= eaks down their strategy, results, and example ads.

Read the Delve case study.

Handling unique indexes on = large data in PostgreSQL (10 minute read)

PostgreSQL has a limitation on unique i= ndex entries larger than 1/3 of a buffer page. The 1/3 page size limit exis= ts to ensure efficient page splitting. To overcome the restriction, introdu= ce a new field that stores a hash of the large field. This allows you to st= ore really large data inside databases, even with unique constraints.
Adding a feature because Ch= atGPT incorrectly thinks it exists (5 minute read)

Soundslice is a service that scans shee= t music from photographs so users can listen, edit, and practice. Over the = past few months, the team at Soundslice started noticing that their error l= ogs were full of ASCII tablature, a way of notating music for guitar that t= he service didn't support. The team discovered that ChatGPT was hallucinati= ng instructions to users and telling them to go to Soundslice and use a fea= ture that didn't exist. Instead of posting a notice telling users that Chat= GPT was incorrect, the team decided to build the feature instead.
=F0=9F= =8E=81

Miscellaneous

<= /div>
Why I used to prefer permis= sive licenses and now favor copyleft (10 minute read)

Free open source software is usually pu= blished under one of two major categories of copyright licenses: permissive= licenses, which freely share with everyone, or copyleft licenses, which fr= eely share only with those who are also willing to freely share. Copyleft c= reates a large pool of code that developers can only legally use if they ar= e willing to share the source code of anything they build on it, making it = a very broad-based and neutral way of incentivizing more diffusion. It does= not favor specific actors nor create roles for active parameter setting by= central planners.
The Broken Microsoft Pact: = Layoffs and Performance Management (9 minute read)

There are stories of people who have be= en with Microsoft for 20 years, who grew up with the company, and who never= had to worry about sudden changes. While the performance management system= had its quirks, there was an understanding that if you did solid work, you= 'd have a place. Workers at Microsoft received below-market-rate pay in exc= hange for stability, a reasonable work-life balance, and the promise of no = layoffs - this is no longer the case. This shift was almost expected: Micro= soft's performance management challenges made layoffs a more attractive opt= ion than addressing individual performance issues systematically.
=E2=9A= =A1

Quick Links

OpenAI Ramps Up Stock Pay t= o $4.4 billion to Combat Meta's Costly Talent Raids (3 minute read)

OpenAI is dramatically increasing its e= mployee stock compensation to defend against rival Meta's poaching.
Waymo robotaxis are heading= to Philadelphia and NYC (2 minute read)

Waymo kicked off two 'road trips' to Ph= iladelphia and New York City yesterday - these branded 'road trips' don't n= ecessarily signal a commercial launch, but it has happened before.
Apple Loses Top AI Models E= xecutive to Meta's Hiring Spree (6 minute read)

Ruoming Pang, the executive in charge o= f Apple's foundation models team, is departing the company for Meta, who of= fered Pang a package worth tens of millions of dollars per year.
What Would Stripe L1 Look L= ike? (13 minute read)

A Stripe L1 should support stablecoin u= se and Stripe L1 integration for customer payments and merchant settlement.
Tech hiring is not the same= as it was even a year ago (1 minute read)

Hiring for new graduates in Big Tech is= down 25% and -11% for startups.
Unless users take action, A= ndroid will let Gemini access third-party apps (6 minute read)

Google is implementing a change that wi= ll enable its Gemini AI engine to interact with third-party apps even if us= ers have configured their devices to block such interactions.

Love TLDR? Tell your friends and get rewards!

Share your referral link below with friends to get free TLDR swag!
Track your referrals here.

Want to advertise in TLDR? =F0=9F=93=B0

If your company is interested in reaching an audience of tech executives, d= ecision-makers and engineers, you may want to advertise with us.

Want to work at TLDR? =F0=9F=92=BC

Apply here or send a friend's resume to jobs@tldr.tech and get $1k if we hire them!

If you have any comments or feedback, just respond to this email!

Thanks for reading,
Dan Ni &a= mp; Stephen = Flanders


Manage your subscriptions to our other newsletters on tech, st= artups, and programming. Or if TLDR isn't for you, please unsubscribe.
3D"" --OOtqTv52-- --- þ Synchronet þ Vertrauen þ Home of Synchronet þ [vert/cvs/bbs].synchro.net .