Subj : Alphabet's AI drug trials ¨, Jack Dorsey's WhatsApp competitor ¨, copyleft vs permissive licenses ¨¨
To : All
From : TLDR
Date : Tue Jul 08 2025 10:46:35
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Isomorphic Labs, Alphabet's secretive drug discovery arm, was born
from o=
ne of DeepMind's most celebrated breakthroughs,
AlphaFold=C2=A0=E2=80=
=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=
=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=
=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=
=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=
=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=
=E2=80=8C=C2=A0=E2=80=8C=C2=A0=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=
=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=
=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=
=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=
=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=
=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0=E2=80=8C=C2=A0
=
Sign Up [1] |Advertise [2]|View Online [3]=20
=09=09TLDR=20
=09=
=09TOGETHER WITH [Pacaso] [4]
TLDR 2025-07-08
3 THINGS VENTURE C=
APITAL FIRMS LOOK FOR (SPONSOR) [4]=20
For VCs, the best investments ch=
eck three boxes: a massive market, a
clear pain point, and founder-market=
fit.=C2=A0
No wonder prominent firms like Maveron backed Pacaso.
=
In the $1.3 trillion vacation home market, second homes were either
to=
o expensive or too much hassle. So after successfully exiting his
previou=
s business, a proven real estate founder applied his proptech
expertise [=
4], selling fractions of homes and managing everything
through streamline=
d tech.=C2=A0
That approach has earned Pacaso $110m+ in gross profits =
to date,
including 41% YoY growth last year alone, across 2,000+ happy
=
homeowners.
Join major VCs like Greycroft as a Pacaso investor for jus=
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=F0=9F=93=B1=20
BIG TECH & STARTUPS
ALPHABET=
'S ISOMORPHIC LABS HAS GRAND AMBITIONS TO =E2=80=98SOLVE ALL
DISEASES' WI=
TH AI. NOW, IT'S GEARING UP FOR ITS FIRST HUMAN TRIALS (3
MINUTE READ) [5=
]=20
Isomorphic Labs, Alphabet's secretive drug discovery arm, is
pre=
paring to launch human trials of AI-designed drugs. The company was
born =
from one of DeepMind's most celebrated breakthroughs, AlphaFold,
an AI sy=
stem capable of predicting protein structures and interactions
with a hig=
h level of accuracy. The system has helped researchers
design medicines f=
aster and more precisely.=20
JACK DORSEY LAUNCHES A WHATSAPP MESSAGING =
RIVAL BUILT ON BLUETOOTH (3
MINUTE READ) [6]=20
Bitchat is a decentra=
lized, peer-to-peer messaging app that works
entirely over Bluetooth mesh=
networks - no internet, central servers,
phone numbers, or emails requir=
ed. It enables ephemeral, encrypted
communication - nearby devices form c=
lusters and pass messages from
device to device, allowing them to reach p=
eers beyond standard range,
even without Wi-Fi or cell service. Messages =
are stored only
on-device, disappear by default, and never touch centrali=
zed
infrastructure. A beta version of Bitchat is currently live on
Test=
Flight.=20
=F0=9F=9A=80=20
SCIENCE & FUTURISTIC TECHNOLOGY
CREA=
TING THERAPEUTIC ABUNDANCE (22 MINUTE READ) [7]=20
The invention of new=
medicines is limited by our knowledge of cells
and molecules that can be=
manipulated to treat disease. The cost of
discovering new medicines is i=
ncreasing. New technologies have the
potential to unlock an era of target=
abundance and reverse the long
decline in research and development produ=
ctivity. This could be one of
AI's most important impacts.=20
NUCLEAR=
REACTORS SMALLER THAN A SEMI TRUCK TO BE TESTED IN IDAHO (4
MINUTE READ)=
[8]=20
The US Department of Energy (DoE) has conditionally selected
=
Westinghouse's trailer-sized eVinci test reactor and Radiant's
Kaleidos u=
nit to conduct the first fueled microreactor experiments at
its Demonstra=
tion of Microreactor Experiments (DOME) facility at Idaho
National Labora=
tory. The DOME project considers anything under 50 MW
of power to be a mi=
croreactor - the eVinci is designed to produce 5
megawatts, and the Kalei=
dos can output 1.2 megawatts. The DoE hopes
that microreactors can be use=
d to power small, remote sites. DOME is
designed to be up and running by =
early 2026. It will operate one
experiment at a time for six months.=20
=
=F0=9F=92=BB=20
PROGRAMMING, DESIGN & DATA SCIENCE
DELVE GENERA=
TED $1M IN PIPELINE FROM TLDR NEWSLETTER ADS (SPONSOR)
[9]=20
Delve r=
an 4 ads across 2 TLDR newsletters and brought in 66 leads,
with a meanin=
gful chunk from enterprise. The result: $1M in attributed
pipeline and a =
52x ROI.
This case study breaks down their strategy, results, and exam=
ple ads.
Read the Delve case study. [9]
HANDLING UNIQUE INDEXES =
ON LARGE DATA IN POSTGRESQL (10 MINUTE READ)
[10]=20
PostgreSQL has a=
limitation on unique index entries larger than 1/3
of a buffer page. The=
1/3 page size limit exists to ensure efficient
page splitting. To overco=
me the restriction, introduce a new field
that stores a hash of the large=
field. This allows you to store really
large data inside databases, even=
with unique constraints.=20
ADDING A FEATURE BECAUSE CHATGPT INCORRECT=
LY THINKS IT EXISTS (5
MINUTE READ) [11]=20
Soundslice is a service t=
hat scans sheet music from photographs so
users can listen, edit, and pra=
ctice. Over the past few months, the
team at Soundslice started noticing =
that their error logs were full of
ASCII tablature, a way of notating mus=
ic for guitar that the service
didn't support. The team discovered that C=
hatGPT was hallucinating
instructions to users and telling them to go to =
Soundslice and use a
feature that didn't exist. Instead of posting a noti=
ce telling users
that ChatGPT was incorrect, the team decided to build th=
e feature
instead.=20
=F0=9F=8E=81=20
MISCELLANEOUS
WHY I USE=
D TO PREFER PERMISSIVE LICENSES AND NOW FAVOR COPYLEFT (10
MINUTE READ) [=
12]=20
Free open source software is usually published under one of two =
major
categories of copyright licenses: permissive licenses, which freely=
share with everyone, or copyleft licenses, which freely share only
wit=
h those who are also willing to freely share. Copyleft creates a
large po=
ol of code that developers can only legally use if they are
willing to sh=
are the source code of anything they build on it, making
it a very broad-=
based and neutral way of incentivizing more diffusion.
It does not favor =
specific actors nor create roles for active
parameter setting by central =
planners.=20
THE BROKEN MICROSOFT PACT: LAYOFFS AND PERFORMANCE MANAGEM=
ENT (9
MINUTE READ) [13]=20
There are stories of people who have been=
with Microsoft for 20
years, who grew up with the company, and who never=
had to worry about
sudden changes. While the performance management syst=
em had its
quirks, there was an understanding that if you did solid work,=
you'd
have a place. Workers at Microsoft received below-market-rate pay =
in
exchange for stability, a reasonable work-life balance, and the
prom=
ise of no layoffs - this is no longer the case. This shift was
almost exp=
ected: Microsoft's performance management challenges made
layoffs a more =
attractive option than addressing individual
performance issues systemati=
cally.=20
=E2=9A=A1=20
QUICK LINKS
OPENAI RAMPS UP STOCK PAY TO=
$4.4 BILLION TO COMBAT META'S COSTLY
TALENT RAIDS (3 MINUTE READ) [14] =
OpenAI is dramatically increasing its employee stock compensation to=
defend against rival Meta's poaching.=20
WAYMO ROBOTAXIS ARE HEADING=
TO PHILADELPHIA AND NYC (2 MINUTE READ)
[15]=20
Waymo kicked off two=
'road trips' to Philadelphia and New York City
yesterday - these branded=
'road trips' don't necessarily signal a
commercial launch, but it has ha=
ppened before.=20
APPLE LOSES TOP AI MODELS EXECUTIVE TO META'S HIRING =
SPREE (6 MINUTE
READ) [16]=20
Ruoming Pang, the executive in charge o=
f Apple's foundation models
team, is departing the company for Meta, who =
offered Pang a package
worth tens of millions of dollars per year.=20
=
WHAT WOULD STRIPE L1 LOOK LIKE? (13 MINUTE READ) [17]=20
A Stripe L1 s=
hould support stablecoin use and Stripe L1 integration
for customer payme=
nts and merchant settlement.=20
TECH HIRING IS NOT THE SAME AS IT WAS E=
VEN A YEAR AGO (1 MINUTE READ)
[18]=20
Hiring for new graduates in Bi=
g Tech is down 25% and -11% for
startups.=20
UNLESS USERS TAKE ACTION=
, ANDROID WILL LET GEMINI ACCESS THIRD-PARTY
APPS (6 MINUTE READ) [19] =
Google is implementing a change that will enable its Gemini AI engin=
e
to interact with third-party apps even if users have configured their=
devices to block such interactions.=20
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--OOtqTv52
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TLDR
Isomorphic=
Labs, Alphabet's secretive drug discovery arm, was born from one of D=
eepMind's most celebrated breakthroughs, AlphaFold =E2=80=8C =
;=E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =
;=E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =
;=E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =
;=E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =
;=E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =
; =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=
=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=
=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=
=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=
=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=8C =E2=80=
=8C =E2=80=8C
Jack Dorsey launches a What=
sApp messaging rival built on Bluetooth (3 minute read)
Bitchat is a decentralized, peer-to-pee=
r messaging app that works entirely over Bluetooth mesh networks - no inter=
net, central servers, phone numbers, or emails required. It enables ephemer=
al, encrypted communication - nearby devices form clusters and pass message=
s from device to device, allowing them to reach peers beyond standard range=
, even without Wi-Fi or cell service. Messages are stored only on-device, d=
isappear by default, and never touch centralized infrastructure. A beta ver=
sion of Bitchat is currently live on TestFlight.
|
|
Science & Futuristic Technology
|
Creating therapeutic abunda=
nce (22 minute read)
The invention of new medicines is limit=
ed by our knowledge of cells and molecules that can be manipulated to treat=
disease. The cost of discovering new medicines is increasing. New technolo=
gies have the potential to unlock an era of target abundance and reverse th=
e long decline in research and development productivity. This could be one =
of AI's most important impacts.
|
Nuclear reactors smaller th=
an a semi truck to be tested in Idaho (4 minute read)
The US Department of Energy (DoE) has c=
onditionally selected Westinghouse's trailer-sized eVinci test reactor and =
Radiant's Kaleidos unit to conduct the first fueled microreactor experiment=
s at its Demonstration of Microreactor Experiments (DOME) facility at Idaho=
National Laboratory. The DOME project considers anything under 50 MW of po=
wer to be a microreactor - the eVinci is designed to produce 5 megawatts, a=
nd the Kaleidos can output 1.2 megawatts. The DoE hopes that microreactors =
can be used to power small, remote sites. DOME is designed to be up and run=
ning by early 2026. It will operate one experiment at a time for six months=
..
|
|
Programming, Design & Data Science
|
Handling unique indexes on =
large data in PostgreSQL (10 minute read)
PostgreSQL has a limitation on unique i=
ndex entries larger than 1/3 of a buffer page. The 1/3 page size limit exis=
ts to ensure efficient page splitting. To overcome the restriction, introdu=
ce a new field that stores a hash of the large field. This allows you to st=
ore really large data inside databases, even with unique constraints.
|
Adding a feature because Ch=
atGPT incorrectly thinks it exists (5 minute read)
Soundslice is a service that scans shee=
t music from photographs so users can listen, edit, and practice. Over the =
past few months, the team at Soundslice started noticing that their error l=
ogs were full of ASCII tablature, a way of notating music for guitar that t=
he service didn't support. The team discovered that ChatGPT was hallucinati=
ng instructions to users and telling them to go to Soundslice and use a fea=
ture that didn't exist. Instead of posting a notice telling users that Chat=
GPT was incorrect, the team decided to build the feature instead.
|
|
Why I used to prefer permis=
sive licenses and now favor copyleft (10 minute read)
Free open source software is usually pu=
blished under one of two major categories of copyright licenses: permissive=
licenses, which freely share with everyone, or copyleft licenses, which fr=
eely share only with those who are also willing to freely share. Copyleft c=
reates a large pool of code that developers can only legally use if they ar=
e willing to share the source code of anything they build on it, making it =
a very broad-based and neutral way of incentivizing more diffusion. It does=
not favor specific actors nor create roles for active parameter setting by=
central planners.
|
The Broken Microsoft Pact: =
Layoffs and Performance Management (9 minute read)
There are stories of people who have be=
en with Microsoft for 20 years, who grew up with the company, and who never=
had to worry about sudden changes. While the performance management system=
had its quirks, there was an understanding that if you did solid work, you=
'd have a place. Workers at Microsoft received below-market-rate pay in exc=
hange for stability, a reasonable work-life balance, and the promise of no =
layoffs - this is no longer the case. This shift was almost expected: Micro=
soft's performance management challenges made layoffs a more attractive opt=
ion than addressing individual performance issues systematically.
|
|
|
Love TLDR? Tell your friends and get rewards!
|
|
Share your referral link below with friends to get free TLDR swag!
|
|
|
|
Track your referrals here.
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|
Want to advertise in TLDR? =F0=9F=93=B0
If your company is interested in reaching an audience of tech executives, d=
ecision-makers and engineers, you may want to advertise with us.
Want to work at TLDR? =F0=9F=92=BC
Apply here or send a friend's resume to jobs@tldr.tech and get $1k if we hire them!
If you have any comments or feedback, just respond to this email!
Thanks for reading,
Dan Ni &a=
mp; Stephen =
Flanders
|
|
|
|
|
--OOtqTv52--
---
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