STUDIES USING PRIMATES AND OTHER ANIMALS FOR AIDS VACCINE RESEARCH
     
MASTER AGREEMENT ANNOUNCEMENT AVAILABLE:  NCI-CP-95665-45
     
P.T. 34; K.W. 0715008, 0740075, 1002002
     
National Cancer Institute
     
The National Cancer Institute, Division of Cancer Etiology, is soliciting
proposals from offerors with the capability to conduct Task A, B, C-1, C-2 or
any combination listed below.  Separate proposals are required for each task
or subtask.
     
Task A:  Provide non-human primates and, housing, care and health surveillance
for these primates; immunize primates with SIV, HV-1 or HV-2 vaccines (to be
provided by NCI); infect primates with HIV or SIV vaccines and assess the
status of these immunized and infected primates; and conduct other
experiments.
     
Task B:  Provide, house, and care for severe combined immunodeficient (SCID)
mice; reconstitute these animals with human tissue to obtain lymhpoid and/or
cells which can be infected with HIV in the mice; develop methods to
reconstitute the mice with human immune cells; evaluate various antibodies;
and, if suitable systems are developed, conduct immunization in the human-SCID
mice and assess the response.
     
Task C-1:  Provide other animals and house and care for them; infect animals
with virus; determine the immune response; and re-isolate virus from tissues
of infected animals.
     
Task C-2:  Provide animals for immunogenicity studies; house and care for
these animals; immunize these animals, immunize these animals with candidate
vaccines; and provide NCI with sera and cells from immunized animals.
     
The offeror's facilities must conform to the standards for animal care
outlined in the Guide for care and Use of Laboratory Animals as published in
the DHHS publication Number (NIH 85-23) or superseding editions.
     
It is anticipated that a Master Agreement Award will be made for a period of
forty-eight (48) months.  Master Agreements consist of a pool of prequalified
offerors.  After award, groups of Master Agreement holders will be invited to
propose competitively on Master Agreement Orders that will be designed to
accomplish a specific task to be designated by the Government.
     
Master Agreement Announcement No. NCI-95665 for the tasks described above will
be available to interested offerors on approximately October 21, 1989.
Responses will be due approximately 30 days after the publication date of this
announcement.
     
Copies of the RFP may be obtained by sending a written request to:
     
Opal J. Bailey
Contract Specialist
Cancer Etiology Section
Research Contracts Branch
National Cancer Institute
Executive Plaza South, Room 620
Bethesda, Maryland  20850
     
                  Vol. 18, No. 38, October 27, 1989 - Page 3
                                   NIH GUIDE