LARGE BOWEL ADENOMATOUS POLYP DIETARY INTERVENTION STUDY--CLINICAL CENTERS
     
RFP AVAILABLE:  NCI-CN-05220-20
     
P.T. 04; K.W. 0715035, 0705025, 0710095, 0755015
     
National Cancer Institute
     
The National Cancer Institute, Division of Cancer Prevention and Control, is
soliciting proposals for clinical centers to conduct a large bowel adenomatous
polyp dietary intervention study.  This multi-center randomized controlled
intervention study will examine the effect of a low-fat, high-fiber, vegetable
and fruit-enriched diet on the recurrence of adenomatous polyps of the large
bowel.  It is expected that an individual offeror will randomize participants
at a minimum rate of 7 per month, or 170 participants over the two-year
randomization period.  General requirements include identification and accrual
of eligible participants, nutritional education and counselling, participant
follow-up and endpoint assessment.  Intermediate endpoint specimens will be
collected.  Data maintenance and reporting quality control systems will be
supported.  A separate Request for Proposals (RFP) will be issued for a data
and nutrition coordinating center.
     
Date of issuance of the RFP will be approximately October 26, 1989, with a
closing date for receipt of proposals to be approximately January 4, 1990.
The Institute plans to award up to 12 contracts from this solicitation.
     
Copies of RFP No. NCI-CN-05220-20 may be obtained by sending a WRITTEN request
to:
     
Mr. Charles E. Lerner, Contract Specialist
National Institutes of Health
National Cancer Institute
Research Contracts Branch, PCCS
Executive Plaza South, Room 635
Bethesda, Maryland  20892
Telephone:  (301) 496-8603
     
                  Vol. 18, No. 38, October 27, 1989 - Page 1
                                   NIH GUIDE